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Biotinylated Pt(IV) prodrugs with elevated lipophilicity and cytotoxicityстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Spektor Daniil, Erofeev Alexander, Gorelkin Petr, Skvortsov Dmitry, Trigub Alexander, Markova Alina, Nikitina Vita, Ul'yanovskii Nikolai, Shtil Alexander, Semkina Alevtina, Vlasova Kseniya, Zyk Nikolai, Majouga Alexander, Beloglazkina Elena, Krasnovskaya Olga
- Журнал: Dalton Transactions
- Год издания: 2023
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- DOI: 10.1039/D2DT03662B
- Аннотация: A design of Pt(IV) prodrugs with tumor cell targeting moieties leading to increased selectivity is of interest. Herein, we designed a novel Pt(IV) prodrugs with COX-inhibitor naproxen, long-chain hydrophobic stearic acid moiety and biotin as axial ligands. We have established that for Pt(IV) prodrugs with biotin and naproxen or stearate in axial position, the lipophilicity rather than biotin receptors expression is the main factor of cytotoxicity. We also monitored the reduction speed of Pt(IV) prodrug 3 with naproxen and biotin in axial positions in A549 cells using XANES and demonstrated that the prodrug gradually releases cisplatin within 20 hours of incubation.
- Добавил в систему: Спектор Даниил Викторович