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Effect of Hydrated Fullerene C60 in a Wide Concentration Range on Low-Level Photon Emission from Undiluted Human Bloodстатья Исследовательская статья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Yablonskaya O., Voeikov V., Novikov K., Buravleva E., Berdnikova N.
- Журнал: Journal of Biomedical Photonics & Engineering
- Том: 8
- Номер: 4
- Год издания: 2022
- Издательство: Samara National Research University
- Местоположение издательства: Samara
- Первая страница: 040504-1
- Последняя страница: 040504-8
- Номер статьи: 040504
- DOI: 10.18287/JBPE22.08.040504
- Аннотация: Hydrated fullerene C60 (HyFnC60) is a symmetrical molecule of C60 Buckminster fullerene surrounded by a water shell obtained by an original technique. It can act as an antioxidant or a pro-oxidant in various biological objects, depending on the conditions. In this study we added HyFnC60 at a range of concentrations obtained by a method of serial dilutionswith vigorous shaking at each step to whole undiluted blood of healthy donors and hospital patients with COPD and examined lucigenin-enhanced blood chemiluminescence. We have found that HyFnC60 at concentrations of2.5 ´ 10–6 M, 2.5 ´ 10–7 M, 2.5 ´ 10–17 M, and 2.5 ´ 10–19 M increased lucigenin-dependent chemiluminescence in heathy donors’ blood while in blood of patients with COPD it had an opposite effect. This can be interpreted as in healthy donors’ blood reactive oxygen species (ROS) generation is enhanced by HyFnC60 while in patients with a chronic inflammatory disease with already increased ROS generation it is attenuated. This indicates that HyFnC60 preparations even in ultra-high dilutions may play the role of a tuner of the processes with ROS participation. Probable reasons of such action of HyFnC60 on human blood even in ultra-high dilutions are discussed.
- Добавил в систему: Воейков Владимир Леонидович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | статья в журнале | Yablonskaya_Voeikov_et_al_2022_published.pdf | 1,2 МБ | 4 января 2023 [Voeikov] |