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Rapid stimulus-evoked astrocyte Ca2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivoстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 февраля 2014 г.
- Авторы: Lind Barbara Lykke, Brazhe Alexey R., Jessen Sanne Barsballe, Tan Florence C.C., Lauritzen Martin J.
- Журнал: Proceedings of the National Academy of Sciences of the United States of America
- Том: 110
- Номер: 48
- Год издания: 2013
- Издательство: National Academy of Sciences
- Местоположение издательства: United States
- Первая страница: E4678
- Последняя страница: E4687
- DOI: 10.1073/pnas.1310065110
- Аннотация: Increased neuron and astrocyte activity triggers increased brain blood flow, but controversy exists over whether stimulation-induced changes in astrocyte activity are rapid and widespread enough to contribute to brain blood flow control. Here, we provide evidence for stimulus-evoked Ca2+ elevations with rapid onset and short duration in a large proportion of cortical astrocytes in the adult mouse somatosensory cortex. Our improved detection of the fast Ca2+ signals is due to a signal-enhancing analysis of the Ca2+ activity. The rapid stimulation-evoked Ca2+ increases identified in astrocyte somas, processes, and end-feet preceded local vasodilatation. Fast Ca2+ responses in both neurons and astrocytes correlated with synaptic activity, but only the astrocytic responses correlated with the hemodynamic shifts. These data establish that a large proportion of cortical astrocytes have brief Ca2+ responses with a rapid onset in vivo, fast enough to initiate hemodynamic responses or influence synaptic activity.
- Добавил в систему: Браже Алексей Рудольфович