Parahydrogen-Induced Hyperpolarization of Unsaturated Phosphoric Acid Derivatives

Авторы: Zlobina Veronika V., Kiryutin Alexey S., Nikovskiy Igor A., Artyushin Oleg I., Kozinenko Vitaly P., Peregudov Alexander S., Yurkovskaya Alexandra V., Novikov Valentin V.
Журнал: International Journal of Molecular Sciences
Том: 24
Номер: 1
Год издания: 2022
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 557
DOI: 10.3390/ijms24010557
Аннотация: Parahydrogen-induced nuclear polarization offers a significant increase in the sensitivity of NMR spectroscopy to create new probes for medical diagnostics by magnetic resonance imaging. As precursors of the biocompatible hyperpolarized probes, unsaturated derivatives of phosphoric acid, propargyl and allyl phosphates, are proposed. The polarization transfer to 1H and 31P nuclei of the products of their hydrogenation by parahydrogen under the ALTADENA and PASADENA conditions, and by the PH-ECHO-INEPT+ pulse sequence of NMR spectroscopy, resulted in a very high signal amplification, which is among the largest for parahydrogen-induced nuclear polarization transfer to the 31P nucleus.
Добавил в систему: Никовский Игорь Алексеевич

№	Имя	Описание	Имя файла	Размер	Добавлен
1.	eksp_zakl_IntJMolSci.pdf		eksp_zakl_IntJMolSci.pdf	114,2 КБ	18 января 2023 [ArtyushinOI]
2.	ijms-24-00557.pdf		ijms-24-00557.pdf	1,9 МБ	16 января 2023 [suhou]

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