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Recoverinстатья
- Авторы: Philippov PP, Zernii EY
- Сборник: Encyclopedia of Signaling Molecules
- Год издания: 2012
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- DOI: 10.1007/978-1-4419-0461-4
- Аннотация: Recoverin, initially named ‘p26’, is a Ca2+-binding protein with a predominantly retinal localization, which belongs to the neuronal calcium sensor (NCS) protein family. The recoverin molecule consists of 201 amino-acid residues and contains four potential EF-hand Ca2+-binding sites, of which only two — EF-hands 2 and 3 — are capable of binding calcium. The N-terminus of recoverin is acylated, mainly myristoylated. Due to the mechanism of Ca2+-myristoyl switch, compartmentalization of recoverin is changed from a soluble Ca2+-free form to a membrane-bound Ca2+-containing form, and vice versa, depending on an external calcium concentration. In the Ca2+-free form, the N-terminal myristoyl moiety of recoverin is buried into the hydrophobic pocket of the protein; on calcium binding, the myristoylated N terminus is exposed, providing membrane association of recoverin. Recoverin is suggested to operate as a Ca2+-sensor of rhodopsin kinase (G-protein-coupled receptor kinase 1, GRK-1), which catalyzes phosphorylation and thus desensitization of the visual receptor rhodopsin. In cancer, recoverin can also be a paraneoplastic (or onconeural) antigen, the aberrant expression of which in malignant tumors of some patients causes an autoimmune response and the development of paraneoplastic retina degeneration or cancer-associated retinopathy. An important feature of the CAR syndrome and underlying autoantibodies against recoverin is that they can be detected long before the clinical diagnosis of the corresponding tumor. Such a feature of the autoantibodies could be useful to clinicians to predict the future development of a particular cancer.
- Добавил в систему: Зерний Евгений Юрьевич