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Hypermethylation of Long Non-Coding RNA Genes Group in the Breast Cancer Development and Progressionстатья
- Авторы: Selezneva AD, Filippova EA, Selezneva AD, SS Lukina, Pronina Ivanova NA, Kazubskaya TP, Burdennyy AM, Braga EA, Loginov
- Журнал: Bulletin of Experimental Biology and Medicine
- Том: 173
- Номер: 6
- Год издания: 2022
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 765
- Последняя страница: 769
- DOI: 10.1007/s10517-022-05627-8
- Аннотация: We analyzed changes in the level of methylation of CpG islands in four long non-coding RNA (lncRNA) genes MEG3, ZNF667-AS1, GAS5, and SEMA3B-AS1 as promising markers of breast cancer. Methylation analysis was performed by quantitative methylation-specific PCR on a set of 38 paired (tumor/normal) breast cancer samples. Significantly (p<0.001) increased methylation was shown for three of the four lncRNA genes: MEG3, ZNF667-AS1, and SEMA3B-AS1. We found significant correlations of the methylation level of all the studied lncRNA genes with the stage of cancer and with lymphogenic metastasis, and for MEG3 and ZNF667-AS1 also with the tumor size. Methylation of ZNF667-AS1, and SEMA3B-AS1 genes in breast cancer was detected for the first time. Based on these findings, new potential markers for the diagnosis and prognosis of breast cancer can be proposed.
- Добавил в систему: Брага Элеонора Александровна