Doxorubicin compositions with biocompatible terpolymer of N-vinylpyrrolidone, methacrylic acid and triethylene glycol dimethacrylateстатьяИсследовательская статья
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Аннотация:Compositions of doxorubicin with a terpolymer of N-vinylpyrrolidone methacrylic acid and triethylene glycol dimethacrylate have been prepared and investigated by UV-VIS and NMR spectroscopy, cyclic voltammetry and DFT quantum-chemical modeling. Oxygen containing groups of the terpolymer and hydrogen atoms of the drug OH groups form hydrogen bonds The compositions have lower cytotoxicity in vitro compared with free doxorubicin.