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Organometallic Iridium Complexes with Glucose Based Phosphite Ligandsстатья Исследовательская статья
- Авторы: Gonchar Maria R., Ninin Fedor S., Mazur Dmitrii M., Lyssenko Konstantin A., Milaeva Elena R., Nazarov Alexey A.
- Журнал: INORGANICS
- Том: 11
- Год издания: 2023
- Издательство: Molecular Diversity Preservation International (MDPI)
- Местоположение издательства: Basel, Switzerland
- Номер статьи: 124
- DOI: 10.3390/inorganics11030124
- Аннотация: New organometallic iridium compounds with phosphorus modified glucose ligands containing isopropylidene protection group or bearing uracil, thymine, and 5-fluorouracil (3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, 3,5,6-bicyclophosphite-1-β-D-glucofuranosyluracil, 3,5,6-bicyclophosphite-1-β-D-glucofuranosylthymine, 3,5,6-bicyclophosphite-1-β-D-glucofuranosyl-5-flurouracil) were prepared. The structure of the new complexes was confirmed by the spectroscopic technique (1H, 31P{1H} NMR) and mass spectrometry, and purity by elemental analysis. The molecular structure of the complex with the isopropylidene protection group was established by the X-ray analysis. The antiproliferative activity of the new iridium compounds was evaluated against several cancer cell lines of human origin, and all compounds showed low toxicity independent of the pyrimidine base nature, attached to the sugar unit.
- Добавил в систему: Назаров Алексей Анатольевич