Regio- and stereochemical features of the reactions of 1,2,5-trimethylpiperidin-4-one with chalconeстатья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:The reactions of N-substituted piperidin-4-ones with benzylideneacetophenone, resulting in the synthesis of a number of heterocyclic 1,5-dicarbonyl compounds, were studied. 1,2,5-Tri-methylpiperidin -4-one enters into cascade-type chalcone addition accompanied by intramolecular aldol condensation giving rise to the 3-azabicyclo[3.3.1]nonane system. The conformations of the 1,5-dicarbonyl compounds and azabicyclononanes synthesized were determined; the regio- and stereochemical features of the reactions of 1, 2,5-trimethylpiperidin-4-one with chalcone were studied.