Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization

Gorshkova, E.A.; Gubernatorova, E.O.; Dvorianinova, E.M.; Yurakova, T.R.; Marey, M.V.; Averina, O.A.; Holtze, S.; Hildebrandt, T.B.; Dmitriev, A.A.; Drutskaya, M.S.; Vyssokikh, M.Y.; Nedospasov, S.A.

Авторы: Gorshkova Ekaterina A., Gubernatorova Ekaterina O., Dvorianinova Ekaterina M., Yurakova Taisiya R., Marey Maria V., Averina Olga A., Holtze Susanne, Hildebrandt Thomas B., Dmitriev Alexey A., Drutskaya Marina S., Vyssokikh Mikhail Yu, Nedospasov Sergei A.
Журнал: Frontiers in immunology
Том: 14
Год издания: 2023
Издательство: Frontiers Research Foundation]
Местоположение издательства: [Lausanne, Switzerland
Первая страница: 1172467
DOI: 10.3389/fimmu.2023.1172467
Аннотация: The naked mole-rat (NMR) is a unique long-lived rodent which is highly resistant to age-associated disorders and cancer. The immune system of NMR possesses a distinct cellular composition with the prevalence of myeloid cells. Thus, the detailed phenotypical and functional assessment of NMR myeloid cell compartment may uncover novel mechanisms of immunoregulation and healthy aging. In this study gene expression signatures, reactive nitrogen species and cytokine production, as well as metabolic activity of classically (M1) and alternatively (M2) activated NMR bone marrow-derived macrophages (BMDM) were examined. Polarization of NMR macrophages under pro-inflammatory conditions led to expected M1 phenotype characterized by increased pro-inflammatory gene expression, cytokine production and aerobic glycolysis, but paralleled by reduced production of nitric oxide (NO). Under systemic LPS-induced inflammatory conditions NO production also was not detected in NMR blood monocytes. Altogether, our results indicate that NMR macrophages are capable of transcriptional and metabolic reprogramming under polarizing stimuli, however, NMR M1 possesses species-specific signatures as compared to murine M1, implicating distinct adaptations in NMR immune system.
Добавил в систему: Горшкова Екатерина Александровна

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Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarizationстатья

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