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Effect of mobile phase composition on the enantioselectivity of chromatographic separation on a quinine-bonded silica stationary phaseстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 3 мая 2017 г.
- Авторы: Nesterenko P.N., Krotov V.V., Staroverov S.M.
- Журнал: Journal of Chromatography A
- Том: 667
- Номер: 1-2
- Год издания: 1994
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 19
- Последняя страница: 28
- DOI: 10.1016/0021-9673(94)89047-1
- Аннотация: The effect of the nature and of the composition eluent on the enantiomer separation of 2,2,2-trifluoro-1-(9-anthryl)ethanol (TFAE) on a chiral stationary phase under HPLC conditions was studied. A series of solvents with different properties were examined as the mobile phase. The best enantioselectivity was achieved with pure benzene, methylene chloride and carbon tetrachloride. The results obtained are discussed in accordance with the three-point interaction model and solvatochromic parameters of the solvents. It is shown that the selectivity of enantiomer separation depends mainly on the hydrogen-accepting ability and dipolarity-polarizability parameters of the solvent. A simplified model of the retention and separation of TFAE enantiomers is proposed. © 1994.
- Добавил в систему: Нестеренко Павел Николаевич