Evolution of homology: From archetype towards a holistic concept of cell type

Rusin, L.Y.

Автор: Rusin Leonid Y.
Журнал: Journal of Morphology
Том: 284
Номер: 4
Год издания: 2023
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Номер статьи: e21569
DOI: 10.1002/jmor.21569
Аннотация: The concept of homology lies in the heart of comparative biological science. The distinction between homology as structure and analogy as function has shaped the evolutionary paradigm for a century and formed the axis of comparative anatomy andembryology, which accept the identity of structure as a ground measure of relatedness. The advent of single‐cell genomics overturned the classical view of cell homology by establishing a backbone regulatory identity of cell types, the basic biological unitsbridging the molecular and phenotypic dimensions, to reveal that the cell is the most flexible unit of living matter and that many approaches of classical biology need to be revised to understand evolution and diversity at the cellular level. The emerging theory ofcell types explicitly decouples cell identity from phenotype, essentially allowing for the divergence of evolutionarily related morphotypes beyond recognition, as well as it decouples ontogenetic cell lineage from cell‐type phylogeny, whereby explicating thatcell types can share common descent regardless of their structure, function or developmental origin. The article succinctly summarizes current progress and opinion in this field and formulates a more generalistic view of biological cell types as avatars,transient or terminal cell states deployed in a continuum of states by the developmental programme of one and the same omnipotent cell, capable of changing or combining identities with distinct evolutionary histories or inventing ad hoc identities that neverexisted in evolution or development. It highlights how the new logic grounded in the regulatory nature of cell identity transforms the concepts of cell homology and phenotypic stability, suggesting that cellular evolution is inherently and massivelynetwork‐like, with one‐to‐one homologies being rather uncommon and restricted to shallower levels of the animal tree of life.
Добавил в систему: Русин Леонид Юрьевич

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Evolution of homology: From archetype towards a holistic concept of cell typeстатья Исследовательская статья

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