Complexation between chitosan and carboxymethyl cellulose in weakly acidic, neutral, and weakly alcaline media

Blagodatskikh, I.V.; Vyshivannaya, O.V.; Tishchenko, N.A.; Orlov, V.N.; Tikhonov, V.E.; Bezrodnykh, E.A.; Ezernitskaya, M.A.; Khokhlov, A.R.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 апреля 2024 г.

Авторы: Blagodatskikh Inesa V., Vyshivannaya Oxana V., Tishchenko Nikita A., Orlov Victor N., Tikhonov Vladimir E., Bezrodnykh Evgeniya A., Ezernitskaya Mariam A., Khokhlov Alexey R.
Журнал: International Journal of Biological Macromolecules
Том: 243
Год издания: 2023
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 125277
DOI: 10.1016/j.ijbiomac.2023.125277
Аннотация: The interaction between carboxymethyl cellulose and partially reacetylated chitosan soluble in acidic and alkaline aqueous media is studied by light scattering and isothermal titration calorimetry in a wide pH range. It is shown that the formation of polyelectrolyte complexes (PEC) can occur in the pH range of 6–8, while this pair of polyelectrolytes loses the ability to complexation upon transition to a more alkaline medium. The revealed dependence of the observed enthalpy of interaction on the ionization enthalpy of the buffer indicates the participation of proton transfer from the buffer substance to chitosan and its additional ionization in the binding process. This phenomenon is first observed in a mixture of a weak polybase chitosan and a weak polyacid. The possibility to obtain soluble nonstoichiometric PEC by a direct mixing of the components in a weakly alkaline medium is shown. The resulting PECs are polymolecular particles in shape close to homogeneous spheres with a radius of about 100 nm. The obtained results are promising for creating of biocompatible and biodegradable drug delivery systems.
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Complexation between chitosan and carboxymethyl cellulose in weakly acidic, neutral, and weakly alcaline mediaстатья

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