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MR-spectroscopy of asparagine in hippocampus and human working memory functioningтезисы доклада
- Авторы: Kozlovskiy S.A., Vartanov A.V., Pyasik M.M., Polikanova I.S.
- Сборник: 14th International Neuroscience Winter Conference, Sölden Austria, April 10 – April 14
- Тезисы
- Год издания: 2012
- Место издания: Austrian Neuroscience Association Sölden
- Первая страница: 32
- Последняя страница: 32
- Аннотация: Recent studies show, that asparagine level in hippocampus might correspond with memory functioning. For example, decreased asparagine level in hippocampus results in spatial memory deficiency in mice (Kwon et al., 2000). Furthermore, it is known, that asparagine affects normal long-term potentiation (LTP) process in rat hippocampus (Kapai et al., 2004). In present study we compared asparagine level in both hippocampi with working memory tests performance in healthy humans. Methods. Participants in the study were 8 right-handed females (mean age – 59±16) without neurological and mental disorders. All subjects performed working memory tests – verbal and spatial N-back task (1-back & 2-back variations). Asparagine levels in hippocampi of both hemispheres were measured with proton magnetic resonance spectroscopy performed with 3T MRI scanner. As a control measurement we used asparagine level in inferior parietal cortex. The received data was analyzed by calculating non-parametric correlations (Spearman, p < 0.05) between individual behavioral and biochemical measurements. Results and conclusions. According to the obtained data, significant correlations between asparagine level in right hippocampus and verbal N-back task were revealed. Moreover, these correlations were revealed in both 1-back variation of the task (0.91) and 2-back variation (0.79). Asparagine level in left hippocampus correlates negatively (-0.68) with spatial 1-back task performance. No relevant correlations between asparagine level in inferior parietal cortex and memory tests performance were revealed. Thus, relatively high asparagine level in right hippocampus associates with verbal memory tests performance, whereas decreased asparagine level in left hippocampus correlates with spatial memory tests performance.
- Добавил в систему: Вартанов Александр Валентинович