Antihypoxic activity of the dry extract from Nepeta multifida Lстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
Авторы:
Razuvaeva Y.G. ,
Toropova A.A.,
Olennikov D.N. ,
Kharzheev D.V.
Журнал:
Natural Product Research
Том:
36
Номер:
12
Год издания:
2022
Издательство:
Taylor & Francis
Местоположение издательства:
United Kingdom
Первая страница:
3105
Последняя страница:
3109
DOI:
10.1080/14786419.2021.1935932
Аннотация:
The antihypoxic effect of the Nepeta multifida L. dry extract was studied in experiments on white Wistar rats. The life span of animals was determined against the background of acute hypoxias: hypercapnic, hemic, and histotoxic ones. Using the model of acute hypobaric hypoxia/reoxygenation there was evaluated the content of ATP, lactic and pyruvic acids, TBA-active products, reduced glutathione, catalase activity in brain tissue. On the model of acute hypobaric hypoxia/reoxygenation, the content of ATP, lactic and pyruvic acids, reduced glutathione and catalase activity in brain tissue The N. multifida dry extract demonstrated antihypoxic effect at the doses comprised between 100 and 300 mg/kg increasing lifespan of animals in hypercapnic, hemic and histotoxic hypoxias. N. multifida decreases the manifestation of free-radical oxidation processes, increases the activity of the endogenic antioxidant system, and promotes the efficacy of tissue respiration and oxidative phosphorylation coupling in the brain of white rats in hypoxia/reoxygenation. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Добавил в систему:
Оленников Даниил Николаевич