Phenylpropanoids from Parasenecio hastatus (Compositae) and Their Wound-Healing Activityстатья
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Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
Авторы:
Olennikov D.N. ,
Chirikova N.K. ,
Tsyrenzhapov A.V.
Журнал:
Russian Journal of Bioorganic Chemistry
Том:
47
Номер:
7
Год издания:
2021
Издательство:
Maik Nauka/Interperiodica Publishing
Местоположение издательства:
Russian Federation
Первая страница:
1411
Последняя страница:
1417
DOI:
10.1134/S106816202107013X
Аннотация:
Abstract: The Parasenecio hastatus (L.) H. Koyama (Cacalia hastata L., Compositae) is a well-known medicinal plant that is widespread in Siberia and the southeast Asia and widely used in the practice of the traditional medicine of Asian countries as a wound-healing agent. The efficacy of the P. hastatus-containing medicines has been confirmed by scientific studies, but the active substances have still not been identified. We demonstrated in this study that the butanol fraction of the P. hastatus leaves exhibited the most pronounced wound-healing effect. Twelve phenylpropanoids were isolated by a chromatographic fractionation of this fraction. They were identified as 5-O-caffeoylquinic acid, caffeic acid, 4-O-caffeoylquinic acid (was first identified for this species), 1,5-di-O-caffeoylquinic acid, 3,4-di-O-caffeoylquinic acid, 3,5-di-O-caffeoylquinic acid, 4,5-di-O-caffeoylquinic acid, 3,4,5-tri-O-caffeoylquinic acid, chichoric acid, 3-O-feruloylquinic acid, 5-O-feruloylquinic acid, and echinacoside. We established by the microcolumn HPLC that the maximum amount of phenylpropanoids was observed in the P. hastatus leaves in the phase of the mass blossoming (up to 60.83 mg/g). 5-O-Caffeoylquinic acid (16.34–39.37 mg/g) and 3,5-di-O-caffeoylquinic acid (10.77–22.87 mg/g) were dominant components in the complex of phenolic compounds and the main active substances that were responsible for the wound-healing effect of the P. hastatus. The activity of 3,5-di-O-caffeoylquinic acid was found to be higher than that of 5-O-caffeoylquinic acid. Thus, we demonstrated that caffeoylquinic acids and therapeutic agents containing these acids were promising wound-healing agents. © 2021, Pleiades Publishing, Ltd.
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Оленников Даниил Николаевич