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The Solubility Studies and the Complexation Mechanism Investigations of Biologically Active Spiro[cyclopropane-1,3′-oxindoles] with β-Cyclodextrinsстатья
- Авторы: Kravtsova Anna A., Skuredina Anna A., Malyshev Alexander S., Le-Deygen Irina M., Kudryashova Elena V., Budynina Ekaterina M.
- Сборник: Applications of Crystal Engineering in Drug Delivery
- Серия: pharmaceutics
- Глава в коллективной монографии
- Год издания: 2023
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 119
- Последняя страница: 136
- DOI: 10.3390/books978-3-0365-8095-1
- Аннотация: Crystal engineering is a broad area of research that includes crystal habit modification,polymorphism, solid dispersions, and salt formation. All these pre-formulation and formulationtechniques imply that the drug can be modified using methods such as solvent evaporation ormechanochemical activation. The drug properties can often be significantly altered when thecrystalline structure is modified, such as in the case of amorphous form formation. The outcome ofsuch modifications affects physical properties and can dramatically impact physiological properties,such as bioavailability and absorption. Recent advances in this area of research have shown thepotential application of crystal engineering to achieve targeted drug delivery for novel molecules,such as anticancer drugs, antimicrobials, and vaccines. Drug delivery applications include variousroutes, such as oral, pulmonary, ophthalmic, buccal, vaginal, transdermal, and parenteral.
- Добавил в систему: Кудряшова Елена Вадимовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Applications_of_Crystal_Engineering_in_Drug_Delivery.pdf | 48,9 МБ | 13 сентября 2023 [Lisitsyna89] |