|
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ЦЭМИ РАН |
||
’Conserved hypothetical’ proteins: Prioritization of targets for experimental studyстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 5 июня 2017 г.
- Авторы: Galperin M.Y., Koonin E.V.
- Журнал: Nucleic Acids Research
- Том: 32
- Номер: 18
- Год издания: 2004
- Издательство: Oxford University Press
- Местоположение издательства: United Kingdom
- Первая страница: 5452
- Последняя страница: 5463
- DOI: 10.1093/nar/gkh885
- Аннотация: Comparative genomics shows that a substantial fraction of the genes in sequenced genomes encodes ’conserved hypothetical’ proteins, i.e. those that are found in organisms from several phylogenetic lineages but have not been functionally characterized. Here, we briefly discuss recent progress in functional characterization of prokaryotic ’conserved hypothetical’ proteins and the possible criteria for prioritizing targets for experimental study. Based on these criteria, the chief one being wide phyletic spread, we offer two ’top 10’ lists of highly attractive targets. The first list consists of proteins for which biochemical activity could be predicted with reasonable confidence but the biological function was predicted only in general terms, if at all (’known unknowns’). The second list includes proteins for which there is no prediction of biochemical activity, even if, for some, general biological clues exist (’unknown unknowns’). The experimental characterization of these and other ’conserved hypothetical’ proteins is expected to reveal new, crucial aspects of microbial biology and could also lead to better functional rediction for medically relevant human homologs. © Oxford University Press 2004; all rights reserved.
- Добавил в систему: Galperin Michael Y.