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Synthesis, antiradical activity and in vitro cytotoxicity of novel organotin complexes based on 2,6-di-tert-butyl-4-mercaptophenolстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 19 июня 2014 г.
- Авторы: Shpakovsky D.B., Banti C.N., Mukhatova E.M., Gracheva Yu A., Osipova V.P., Berberova N.T., Albov D.V., Antonenko T.A., Aslanov L.A., Milaeva E.R., Hadjikakou S.K.
- Журнал: Dalton Transactions
- Том: 43
- Номер: 18
- Год издания: 2014
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 6880
- Последняя страница: 6890
- DOI: 10.1039/C3DT53469C
- Аннотация: A series of organotin complexes with Sn-S bonds of formulae Me2Sn(SR)2 (1); Et2Sn(SR)2 (2); (n-Bu)2Sn(SR)2 (3); Ph2Sn(SR)2 (4); R2Sn(SR)2 (5); Me3SnSR (6) Ph3SnSR (7) (R= 3,5-di-tert-butyl-4-hydroxyphenyl) were synthesized and characterized by elemental analysis, 1H, 13C NMR, IR. The crystal structures of compounds 1,4,5,7 were also determined by X-ray diffraction analysis. The tetrahedral geometry around the Sn center in the monocrystals of 1,4,5,7 was confirmed by X-ray crystallography. The high radical scavenging activity of the complexes was confirmed spectrophotometrically in DPPH-test. The binding affinity of 1-7 and the starting R2SnCl2 (8) towards tubulin through their interaction with SH groups of protein was studied. It was found that the hindered organotin complexes could interact with colchicine site of tubulin that makes them promising antimitotic drugs. Compounds 1–8 were tested for their in vitro cytotoxicity against human breast (MCF-7) and human cervix (HeLa) adenocarcinoma cells. Complexes 1–8 were also tested against normal human fetal lung fibroblast cells (MRC-5). Complexes 2-4 and 8 exhibit significantly lower cytostatic activity against normal MRC-5 cell line compared to the tumor cell lines MCF-7 and HeLa used. The high activity against both cell lines 250 nM (MCF-7) and 160 nM (HeLa) was determined for the triphenyltin complex 7 while the introduction of hindered phenol groups decreases the cytotoxicity of complexes against normal cells.
- Добавил в систему: Шпаковский Дмитрий Борисович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Dalton_Trans_2014_43_6880.pdf | 1,4 МБ | 8 апреля 2014 [Dmshpak] |