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HYBRID METAL COMPLEXES WITH OPPOSED BIOLOGICAL MODES OF ACTION – CANDIDATES FOR BIOMEDICAL APPLICATIONтезисы доклада
- Авторы: Milaeva E.R., Shpakovsky D.B., Nazarov A.A., Tyurin V.Yu, Gracheva Yu A., Antonenko T.A., Kharitonashvili E.V.
- Сборник: Book of Abstracts (8th International IUPAC Symposium «Macro- and Supramolecular Architectures and Materials:Multifunctional Materials and Structures» (MAM-17) 6-10 June 2017, Sochi, Russia, ISBN 978-5-7396-0369-2
- Тезисы
- Год издания: 2017
- Место издания: Publishing House of I.M.Sechenov Fitst MSMU Москва
- Первая страница: 58
- Последняя страница: 58
- Аннотация: The oxidative stress is considered to be involved in the pathogenesis of various diseases (cancer, diabetes, neurodegeneration etc.). The antioxidative defense system in the living organism regulates the toxic impact of ROS and there is strong evidence that the antioxidants prevent some pathologies including cancer. The specific chemical properties of metal-based drugs impart innovative pharmacological profiles to this type of therapeutic agents, most likely in relation to novel biomolecular mechanisms. Our study is focused on a novel approach to design polyfunctional metal-based physiollogically active compounds with opposed modes of action – prooxidant metal center and antioxidant 2,6-dialkylphenol group. The synthesis and anti/prooxidant activity and cytotoxicity studies of novel organometallic/coordination compounds (ferrocenes, complexes with di-(2-picolyl)amine ligand, porphyrins, pyridines, thiols, carboxylates) based on either biogenic metals (Fe, Mn, Co, Cu, Zn, Ni) or exogenic metals (Sn, Au, Rh) are presented and discussed.
- Добавил в систему: Милаева Елена Рудольфовна