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Regulation of Uni-Strand and Dual-Strand piRNA Clusters in Germ and Somatic Tissues in Drosophila melanogaster under Control of rhinoстатья
Информация о цитировании статьи получена из
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Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Milyaeva P.A., Lavrenov A.R., Kuzmin I.V., Kim A.I., Nefedova L.N.
- Журнал: Russian Journal of Genetics
- Том: 59
- Номер: 12
- Год издания: 2023
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 1288
- Последняя страница: 1297
- DOI: 10.1134/S1022795423120050
- Аннотация: Drosophila melanogaster is a common genetic object for research of RNA interference pathwaysand regulation of mobile elements. At present, taking part in control of retrotransposon expression, the system of piRNA interference is well studied in ovary tissues. It is strongly believed that, in D. melanogaster, thesystem of piRNA interference is used for retrotransposon suppression only in the gonads, and two distinctpathways of piRNA biogenesis exist. Both mechanisms use transcripts of piRNA clusters (accumulations oftruncated and defective copies of mobile elements): from unistrand clusters in the first case and from dualstrand clusters in the second case, transcribed from one or both DNA chains, respectively. It is well knownthat proper function of dual-strand clusters depends on the gene rhino, while unistrand clusters are transcribed and then spliced independently of rhino. In this paper, we show that rhino participates in splicing ofunistrand cluster flamenco transcripts. Moreover, the system of piRNA interference is necessary for regulationof several retrotransposons not only in the gonads but also in other organs.
- Добавил в систему: Миляева Полина Андреевна