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EEG CORRELATES OF IMPAIRMENT ANTICIPATION PROCESS IN THE EARLY STAGES OF SCHIZOPHRENIAстатья Тезисы
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или ScopusДата последнего поиска статьи во внешних источниках: 24 июля 2024 г.
- Авторы: Slavutskaya M., Lebedeva I., Omelchenko M., Abdullina E., Karelin S.
- Журнал: European Psychiatry
- Том: 65
- Номер: S1
- Год издания: 2022
- Издательство: Cambridge University Press
- Местоположение издательства: United Kingdom
- Первая страница: S315
- Последняя страница: S316
- Аннотация: EEG correlates of impaired prognostic processes in the early stages of schizophrenia Slavutskaya M.V. 1,2, Lebedeva I.S. 2, Omelchinko M.A. 2 ,Karelin S.A1Lomonosov Moscow State University, Biological Faculty1; Mental Health Research Center, Moscow, Russia2; mvslav@yandex.ruAn impaired of prognostic processes is usually considered as a trait deficiency in schizophrenia (Kvaraga et al., 2007), however its neural mechanisms remain poorly understood. The aim of the study was to analyze a CNV-like slow negative waves during the pre-target stimuli waiting period in patients with the first episode of the disease.32-channels EEGs during "Go / No go delay" saccadic paradigm have been recorded in 16 young male patients with illness duration no long than 2 years and 18 age and sex matched healthy subjects. The delay period between fixation and target visual stimulus (“Go” or “No go") was 2800-3000ms. The early and late components of CNV (contingent negative variation) - like slow negative waves (PMN1 and 2) have been studied in 1sec pre-stimulus interval of delay period.As compared to norm, the patients showed significantly increased latencies of saccades to correctly discriminated stimuli and higher percent of "errors saccades". The amplitudes of No go-PMN1 and Go-PMN2 waves were also increased in patients. The amplitude foci of these waves were diffusely distributed in patients and mostly localized in frontal leads in norm. The findings assume some violation of prognostic (for motor or inhibitory response) processes as well as an increase of presumably cortical activation during stimulus anticipation in the “Go/No go delay” saccadic paradigm in the early stage of schizophrenia
- Добавил в систему: Славуцкая Мария Валерьевна