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Hydrogen Inhalation Reduces Lung Inflammation and Blood Pressure in the Experimental Model of Pulmonary Hypertension in Ratsстатья Электронная публикация
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 15 февраля 2024 г.
- Авторы: Kuropatkina Tatyana, Dmitrii Atiakshin, Fedor Sychev, Marina Artemieva, Shishkina Viktoriy, Gufranov Khaydar, Medvedeva Natalia, Medvedev Oleg
- Журнал: BIOMEDICINES
- Том: 11
- Год издания: 2023
- Номер статьи: 3141
- DOI: 10.3390/biomedicines11123141
- Аннотация: Hydrogen has been shown to exhibit selective antioxidant properties against hydroxylradicals, and exerts antioxidant and anti-inflammatory effects. The monocrotaline-induced modelof pulmonary hypertension is suitable for studying substances with antioxidant activity becauseoxidative stress is induced by monocrotaline. On day 1, male Wistar rats were subcutaneouslyinjected with a water–alcohol solution of monocrotaline or a control with an only water–alcoholsolution. One group of monocrotaline-injected animals was placed in a plastic box that was constantlyventilated with atmospheric air containing 4% of molecular hydrogen, and the two groups of rats,injected with monocrotaline or vehicle, were placed in boxes ventilated with atmospheric air. After21 days, hemodynamic parameters were measured under urethane narcosis. The results showedthat, although hydrogen inhalation had no effect on the main markers of pulmonary hypertensioninduced by monocrotaline injection, there was a reduction in systemic blood pressure due to itssystolic component, and a decrease in TGF-β expression, as well as a reduction in tryptase-containingmast cells.
- Добавил в систему: Медведева Наталия Александровна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Статья об эффектах молекулярного водорода на модели легочной гипертензии у крыс | biomedicines-11-03141_fIsos2h.pdf | 2,9 МБ | 25 ноября 2023 [omedvedev] |