Emergent alpha-beta oscillations are accompanied with worsening motor symptoms in Parkinson’s disease

Belova, E.; Semenova, U.; Gamaleya, A.; Tomskiy, A.; Sedov, A.

Авторы: Belova E., Semenova U., Gamaleya A., Tomskiy A., Sedov A.
Журнал: Movement Disorders
Том: 38
Номер: Suppl. 1
Год издания: 2023
Издательство: John Wiley & Sons Inc.
Местоположение издательства: United States
Первая страница: S533
Последняя страница: S533
Номер статьи: 1203
DOI: 10.1002/mds.29544
Аннотация: Objective: The aim of the study was to imply observer-independentapproach to search for the ranges of stable oscillations in broad alpha-betarange inside the STN of patients with PD and to establish associations ofisolated subbands with motor symptoms and DBS set-up.Background: Beta oscillations in the STN contribute to pathophysiological mechanisms of PD, though frequency borders of beta subbandsvary significantly across the studies. Only recently heterogeneity of betarhythmic activity became the focus of research. Recently, alpha oscillations in the STN also has drawn an attention of researchers.Methods: LFP were recorded in the STN during DBS surgeries. Aperiodic component were extracted from the power spectra, and oscillating peaksin 8-35 Hz band with amplitudes exceeding 90% percentile were clusteredinto three sub-bands using Ward’s method. Clinical signs were assessed inpatients with and without oscillation peaks in the lowest alpha-beta subband.Results: Using hierarchical clustering, we separated alpha-beta (8-15 Hz),beta (15-25 Hz) and beta-gamma (25-35 Hz) subbands. Beta peaks were present in almost all inspected nuclei, alpha-beta peaks were found in about halfof subjects, while beta-gamma peaks were rather sparse. Alpha-beta peakswere located more ventromedially compared to beta. Group of subjects withprominent alpha-beta peaks had higher disease duration, bradykinesia andrigidity scores compared to the group without alpha-beta peaks.Conclusions: Splitting LFP spectra using clustering approach resultedin the subbands that shifted relative to conventional borders, and theseoscillations differ not only in in their localization inside the STN but mayalso carry clinically relevant information about the degree of motor impairment along with PD progression. Therefore, increased alpha-beta oscillations may emerge as additional phenomena complementing betaoscillations; they may mark disease progression in PD and affect DBSstimulation setup. Work was funded by RScF (#22-15-00344).
Добавил в систему: Гамалея Анна Александровна

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