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Effects of Prenatal Treatment with Valproic Acid (VPA) on Offspring of Epileptic Adult Rats: MRI Investigationстатья
- Авторы: Anna Petrenko, Mikhail Gulyaev, Dmytriy Tischenko, Valery Petuchov, Kenul Abbasova
- Журнал: Journal of Neuroscience and Neuroengineering
- Том: 2
- Номер: 6
- Год издания: 2013
- Издательство: American Scientific Publishers
- Местоположение издательства: United States
- Первая страница: 562
- Последняя страница: 568
- DOI: 10.1166/jnsne.2013.1085
- Аннотация: The problem of treating epilepsy in pregnant women is being actively researched now as avoiding side effects of anti-convulsant drugs on children remains unsolved. In order to do so it important to understand why do structural effects appear in the first place and why there is observed a problem of a slower development as a result of using wide spread treatment methods. However, there is insufficient data about the influence of prenatal treatment with Valproic Acid (VPA) on changes in the brain structure of offspring of epileptics in adulthood. The aim of this study was to assess long-term brain damage after prenatal exposure to VPA. The offspring (n = 70) of 26 Wistar rats were divided into four groups and treated as follows: valproic acid (VPA—300 mg/kg), pentylenetetrazole (PTZ—75 mg/kg), VPA+PTZ and controls. MRI volumetric and signal analysis of changes in the cortex, hippocampus, thalamus, amygdale and striatum was conducted when the rats reached adulthood. The study provided clear evidence that VPA treatment in pregnancy significantly decreased hippocampal volume in all treatment groups and altered T2 signal intensity in all analysed structures.
- Добавил в систему: Аббасова Кенул Расим кызы
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Effects_of_Prenatal_Treatment_with_Valproic_Acid_VPA_on_Off… | 605,2 КБ | 17 сентября 2018 [akenul] |