Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysis

Cannarella, R.; Shah, R.; Saleh, R.; Boitrelle, F.; Hamoda Taha, A.A.; Singh, R.; Salvio, G.; Toprak, T.; Falcone, M.; Gul, M.; Dimitriadis, F.; Rambhatla, A.; Russo, G.I.; Ko, E.; Zini, A.; Kavoussi, P.; Phuoc Nguyen, H.V.; Kandil, H.; Ghayda, R.A.; Birowo, P.; Gherabi, N.; Ceyhan, E.; Dong, J.; Malhotra, V.; Durairajanayagam, D.; Kolbasi, B.; Bahar, F.; Calik, G.; Çayan, S.; Pinggera, G.; Calogero, A.E.; Rajmil, O.; Mostafa, T.; Atmoko, W.; Harraz, A.M.; Le Tan, V.; de la Rosette, J.; Hakim, L.; Pescatori, E.; Sergeyev, O.; Rashed, A.; Saini, P.; Agarwal, A.

Авторы: Cannarella Rossella, Shah Rupin, Saleh Ramadan, Boitrelle Florence, Hamoda Taha Abo-Almagd Abdel-Meguid, Singh Rajender, Salvio Gianmaria, Toprak Tuncay, Falcone Marco, Gul Murat, Dimitriadis Fotios, Rambhatla Amarnath, Russo Giorgio I., Ko Edmund, Zini Armand, Kavoussi Parviz, Phuoc Nguyen Ho Vinh, Kandil Hussein, Ghayda Ramy Abou, Birowo Ponco, Gherabi Nazim, Ceyhan Erman, Dong Jie, Malhotra Vineet, Durairajanayagam Damayanthi, Kolbasi Bircan, Bahar Fahmi, Calik Gokhan, Çayan Selahittin, Pinggera Germar-Michael, Calogero Aldo E., Rajmil Osvaldo, Mostafa Taymour, Atmoko Widi, Harraz Ahmed M., Le Tan V., de la Rosette Jean, Hakim Lukman, Pescatori Edoardo, Sergeyev Oleg, Rashed Ayman, Saini Pallavi, Agarwal Ashok
Журнал: WORLD JOURNAL OF MENS HEALTH
Том: 42
Год издания: 2024
DOI: 10.5534/wjmh.230235
Аннотация: PurposeVaricoceles can be a source of elevated seminal oxidative stress (OS) and sperm DNA fragmentation (SDF). However, it remains unclear whether varicocele repair (VR) could reduce these parameters. This systematic review and meta-analysis (SRMA) aims to investigate the impact of VR on SDF and seminal malondialdehyde (MDA).Materials and MethodsA literature search was performed in Scopus, PubMed, Ovid, Embase, and Cochrane databases. This SRMA included randomized controlled trials and observational studies reporting the pre- and postoperative levels of SDF and seminal OS in infertile men with clinical varicocele that underwent VR. Subgroup analyses included techniques of VR and SDF testing. The effect size was expressed as standardized mean difference (SMD).ResultsOut of 1,632 abstracts assessed for eligibility, 29 studies with 1,491 infertile men were included. The analysis showed a significant reduction in SDF after VR, compared to preoperative values (SMD −1.125, 95% confidence interval [CI] −1.410, −0.840; p<0.0001) with high inter-study heterogeneity (I2=90.965%). Reduction in SDF was evident with microsurgical technique and non-microsurgical inguinal approaches (SMD −1.014, 95% CI −1.263, −0.765; p<0.0001, and SMD −1.495, 95% CI −2.116, −0.873; p<0.0001), respectively. Reduction in SDF was significant irrespective of testing was done by sperm chromatin dispersion (SMD −2.197, 95% CI −3.187, −1.207; p<0.0001), sperm chromatin structure assay (SMD −0.857, 95% CI −1.156, −0.559; p<0.0001) or TUNEL (SMD −1.599, 95% CI −2.478, −0.719; p<0.0001). A significant decrease in seminal MDA levels was observed following VR (SMD −2.450, 95% CI −3.903 to −0.997, p=0.001) with high inter-study heterogeneity (I2=93.7%).ConclusionsUsing pre- and post-intervention data, this SRMA indicates a significant reduction in SDF and seminal MDA levels in infertile men with clinical varicocele treated with VR. These findings may have important implications for the future management of this selected group of infertile patients.
Добавил в систему: Сергеев Олег Владимирович

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ЦЭМИ РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ЦЭМИ РАН

Effects of Varicocele Repair on Sperm DNA Fragmentation and Seminal Malondialdehyde Levels in Infertile Men with Clinical Varicocele: A Systematic Review and Meta-Analysisстатья Исследовательская статья

Прикрепленные файлы