Аннотация:The paper considers the problem of the economic feasibility of cannabis legalization in the Russian Federation. The paper also analyzes attitudes towards cannabis legalization among 584 residents (291 female and 293 male, 18.8 ± 1.4 for men, 18.3 ± 1.6 for women) from two different Russian regions (with the highest (Republic of Khakassia, Chelyabinsk Region, Moscow Region, Amur Region, and Saint-Petersburg) and lowest (Chukotka Autonomous District, Nenets Autonomous District, Chechen Republic, Arkhangelsk Region, and Orel Region) per capita drug use in the Russian Federation). All participants were interviewed via the Internet. In the first stage, a keyword analysis categorized articles into medical (48 %) and non-medical (52 %) cannabis use, revealing varied perspectives on its benefits and risks. The second stage surveyed Russian citizens, indicating regional differences in attitudes toward cannabis legalization based on per capita drug use. The third stage conducted a PEST analysis, highlighting economic consequences and offering recommendations. Practical implications include the need for targeted prevention programs, effective curriculum modules, and collaborative efforts to address the complex challenges associated with cannabis legalization. The study found that the public attitude towards the legalization of drugs for non-medical purposes is negative. In regions with the highest per capita soft drug use, the legalization of non-medical cannabis is unlikely to cause an increase in the level of usage. Teenagers living in regional centers tend to be more engaged in trying and using cannabis (11.9 %) compared to other cities (8.8 %, p ≤ 0.05) and rural areas, where the rate of cannabis use was the lowest (5.4 %, p ≤ 0.05). This research underscores the importance of tailored interventions and educational strategies to address diverse attitudes toward cannabis legalization. The findings contribute valuable insights for policymakers, educators, and health professionals, guiding the development of informed approaches to substance use prevention. The recommendations emphasize the necessity of proactive measures, such as outreach programs and collaborative efforts, to navigate the multifaceted implications of cannabis legalization and promote overall societal well-being.