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DNIC (nitric oxide donor) Suppresses the Expression of Matrix Metalloproteinase and Poly(ADP-ribose)polymerase Genes in Human Multiple Myeloma Cellsстатья
Дата последнего поиска статьи во внешних источниках: 19 июня 2024 г.
- Авторы: Akentieva Natalia, Sanina Natalia, Gizatullin Artur, Shushanov Sain S.
- Журнал: Letters in Applied NanoBioScience
- Том: 12
- Номер: Принята в печать
- Год издания: 2024
- Издательство: Bucureşti
- Местоположение издательства: Romania
- Первая страница: 1
- Последняя страница: 20
- Номер статьи: Принята в печать
- Аннотация: Poly(ADP-ribose)polymerase plays an important role in various mechanisms of cell death: necrosis, autophagy, and partanatosis. Elevated levels of matrix metalloproteinases correlate with tumor invasiveness and metastasis. Therefore, the search for MMP and PARP inhibitors is important for the development of new anticancer drugs. The effect of DNIC#7 (3.9 x 10-4M) on the expression of poly(ADP-ribose)polymerase (PARP-1 and PARP-2) isoenzyme genes in human multiple myeloma cells was studied. It was shown that DNIC#7 suppresses the expression of PARP-1 genes by 50 %, but activates the expression of PARP-2 genes by 4.5 times. The influence of DNIC#7 on the expression of matrix metalloproteinase (MMP-7, MMP-9) isoenzyme genes in human multiple myeloma cells was studied. It was shown by RT-PCR that DNIC#7 (at a concentration of 3.9 x 10-4 M) suppressed the expression of MMP-7 genes by ~12 times, and MMP-9 by 10 times. The results showed that DNIC#7 is an effective inhibitor of PARP-1, MMP-7 and MMP-9. Therefore, DNIC#7 has antitumor potential for the treatment of human multiple myeloma.
- Добавил в систему: Акентьева Наталья Павловна