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Chitosan/PEG-mediated spinal cord fusion after complete dorsal transection in rabbits – functional results at 30 daysстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 30 января 2024 г.
- Авторы: Lebenstein-Gumovski Michael, Rasueva Tanzila, Zharchenko Alexander, Bashahanov Robert, Kovalev Dmitry A., Zhirov Andrey, Shatokhin Anton, Grin Andrey
- Журнал: Surgical neurology international
- Том: 14
- Номер: 423
- Год издания: 2023
- Издательство: Medknow
- Местоположение издательства: Mumbai, India
- Первая страница: 1
- Последняя страница: 4
- DOI: 10.25259/sni_927_2023
- Аннотация: Background: The aim was to study functional recovery in experimental animals (rabbits) with transected spinal cords treated with a combination of photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol (PEG-chitosan).Methods: 20 rabbits (n = 10 experimental and n = 10 controls) were submitted to complete spinal cord transection at T9. The experimental group received an intraoperative injection of PEG-chitosan. Neurological recovery was assessed using the modified Basso, Beattie, and Bresnahan scale.Results: In the experimental group, partial recovery of movements, sensory function, and sphincter control were all observed by postoperative day 30. Paraplegia and anesthesia persisted in the control group; 4 controls died versus none in the test group.Conclusion: PEG-chitosan is a candidate for neurological restoration after spinal paralysis.Keywords: Chitosan; NeuroPEG; PEG; PEG-chitosan; Polyethylene glycol; Spinal cord injury; Spinal injury.
- Добавил в систему: Лебенштейн-Гумовски Михаил Владимирович