Genetically modified mice as a tool for the study of human diseasesстатья
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Дата последнего поиска статьи во внешних источниках: 30 января 2024 г.
Аннотация:Modeling a human disease is an essential part of biomedical research. The recent advances in the field of molecular genetics
made it possible to obtain genetically modified animals for the study of various diseases. Not only monogenic disorders but
also chromosomal and multifactorial disorders can be mimicked in lab animals due to genetic modification. Even human
infectious diseases can be studied in genetically modified animals. An animal model of a disease enables the tracking of its
pathogenesis and, more importantly, to test new therapies. In the first part of this paper, we review the most common DNA
modification technologies and provide key ideas on specific technology choices according to the task at hand. In the second
part, we focus on the application of genetically modified mice in studying human diseases.