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Identification of Detonation-Nanodiamond Particles and Detection of Their Localization in Human Macrophages and Mouse Lungsстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 февраля 2024 г.
- Авторы: Tarasova E.K., Erokhina M.V., Masyutin A.G., Bocharova I.V., Yakovlev R.Yu, Kuzmin A.A., Lepekha L.N.
- Журнал: Nanobiotechnology Reports
- Том: 18
- Номер: 6
- Год издания: 2023
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 936
- Последняя страница: 944
- DOI: 10.1134/s2635167623601031
- Аннотация: Nanodiamonds modified with functional groups are obtained for targeted drug delivery. A set of methods for identifying nanodiamonds in biological material is determined and their localization in human macrophages and mouse lung cells is identified. It is shown that seven days after introduction into the mouse lungs, nanodiamonds are internalized by endotheliocytes and interstitial macrophages. Both in the human macrophage culture and in the lung cells, nanodiamonds are localized in phagosomes/phagolysosomes. The nanodiamonds do not cause pathological changes in human macrophages and mouse lung cells. The results obtained lead us to consider nanodiamonds as a promising carrier platform for drug delivery, first and foremost to macrophages of the interstitium of the respiratory portion of the lung, which is relevant in such a disease as tuberculosis.
- Добавил в систему: Масютин Александр Георгиевич
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