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Laser rapid prototyping for tissue engineering and regenerationстатья
- Авторы: Popov V.K., Antonov E.N., Bagratashvili V.N., Evseev A.V., Panchenko V.Ya, Barry J.J.A, Howdle S.M.
- Сборник: Proceedings of SPIE - The International Society for Optical Engineering. Advanced Laser Technologies 2006
- Серия: "Advanced Laser Technologies 2006"
- Том: 6606
- Год издания: 2007
- Издательство: SPIE-The International Society for Optical Engineering
- Местоположение издательства: Bellingham, WA, United States
- Первая страница: 66061В
- Аннотация: In present paper we describe the development of advanced laser stereolithography (LS) methodology based on photopolymerisation of a new liquid mixture of polyfunctional acrylic monomers and osteoinductive hydroxyapatite powder. Supercritical carbon dioxide treatment of LS samples introduced both surface and bulk microporosity for enhanced primary cell attachment and to remove toxic additives improving biocompatibility of the materials. The results of in vitro tests comprising human osteoblast cells attachment, spreading and proliferation on the implants demonstrate low level of their cytotoxicity and high level of biocompatibility. We also present a novel Surface Selective Laser Sintering (SSLS) technique for biodegradable polymer scaffolds fabrication from thermosensitive poly(D,L-lactic) - and poly(D,L-lactic-co-glycolic) acids - polymers, which have a wide spread occurrence in biomedical applications. Unlike conventional Selective Laser Sintering (where the powder particles melt because of their volumetric absorption of the laser radiation), in SSLS initiation of the sintering occur due to near IR laser beam absorption by a small amount (<0.1wt.%) of biocompatible carbon black microparticles uniformly distributed along the polymer powder surface...
- Добавил в систему: Панченко Владислав Яковлевич