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G -Quadruplexes as Sensors of Intracellular Na+/K+ Ratio: Potential Role in Regulation of Transcription and Translationстатья
- Авторы: Lopina Olga D., Sidorenko Svetlana V., Fedorov Dmitry A., Klimanova Elizaveta A.
- Журнал: Biochemistry (Moscow)
- Том: 89
- Номер: Suppl. 1
- Год издания: 2024
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: S262
- Последняя страница: S277
- DOI: 10.1134/S0006297924140153
- Аннотация: Data on the structure of G-quadruplexes, noncanonical nucleic acid forms, supporting an idea of their potential participation in regulation of gene expression in response to the change in intracellular Na+i/K+i ratioare considered in the review. Structural variety of G-quadruplexes, role of monovalent cations in formation of this structure, and thermodynamic stability of G-quadruplexes are described. Data on the methods of their identification in the cells and biological functions of these structures are presented. Analysis of information about specific interactions of G-quadruplexes with some proteins was conducted, and their potential participation in the development of some pathological conditions, in particular, cancer and neurodegenerative diseases, is considered.Special attention is given to the plausible role of G-quadruplexes as sensors of intracellular Na+i/K+i ratio, becausealteration of this parameter affects folding of G-quadruplexes changing their stability and, thereby, organization of the regulatory elements of nucleic acids. The data presented in the conclusion section demonstrate significant change in the expression of some early response genes under certain physiological conditions of cells and tissuesdepending on the intracellular Na+i/K+i ratio.
- Добавил в систему: Климанова Елизавета Андреевна