Transient Interphase Microtubules Appear in Differentiating Sponge Cells

Golyshev, S.A.; Lyupina, Y.V.; Kravchuk, O.I.; Mikhailov, K.V.; Gornostaev, N.G.; Burakov, A.V.

Авторы: Golyshev Sergei A., Lyupina Yulia V., Kravchuk Oksana I., Mikhailov Kirill V., Gornostaev Nicolay G., Burakov Anton V.
Журнал: Cells
Том: 13
Номер: 9
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 736
Последняя страница: 736
DOI: 10.3390/cells13090736
Аннотация: Microtubules are an indispensable component of all eukaryotic cells due to their role in mitotic spindle formation, yet their organization and number can vary greatly in the interphase. The last common ancestor of all eukaryotes already had microtubules and microtubule motor proteins moving along them. Sponges are traditionally regarded as the oldest animal phylum. Their body does not have a clear differentiation into tissues, but it contains several distinguishable cell types. The choanocytes stand out among them and are responsible for creating a flow of water with their flagella and increasing the filtering and feeding efficiency of the sponge. Choanocyte flagella contain microtubules, but thus far, observing a developed system of cytoplasmic microtubules in non-flagellated interphase sponge cells has been mostly unsuccessful. In this work, we combine transcriptomic analysis, immunofluorescence, and electron microscopy with time-lapse recording to demonstrate that microtubules appear in the cytoplasm of sponge cells only when transdifferentiation processes are activated. We conclude that dynamic cytoplasmic microtubules in the cells of sponges are not a persistent but rather a transient structure, associated with cellular plasticity.
Добавил в систему: Бураков Антон Владимирович

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Transient Interphase Microtubules Appear in Differentiating Sponge Cellsстатья Исследовательская статья

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