Role of the Mast Cell–Neuron Tandem in Cardiac Function Regulation in Cardiovascular Pathologies

Morozova, M.P.; Kurenkova, A.D.; Umarova, B.A.

Авторы: Morozova M.P., Kurenkova A.D., Umarova B.A.
Журнал: Journal of Evolutionary Biochemistry and Physiology
Том: 60
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 612
Последняя страница: 632
DOI: 10.1134/S0022093024020145
Аннотация: The review addresses new data on the involvement of mast cells (MCs) in the regulation ofcardiac function during the development of some cardiovascular pathologies. Under normal conditions,the number of MCs in the heart is very small compared to their abundance in barrier tissues. Theyprovide cardiac tissue homeostasis and the life-long interaction of the heart with the nervous andendocrine systems. Cardiac pathology is accompanied by the development of the inflammatoryresponse, with MCs playing a significant role at all stages of this process. The number of MCssignificantly increases as myocardial infarction, cardiac fibrosis and coronary atherosclerosis develop.Meanwhile, their pathogenic contribution to cardiovascular pathologies is ambiguous because, on theone hand, it is aimed at cardiac tissue adaptation to injury, while on the other hand, the avalanche-likesynthesis and release of mediators from activated MCs exacerbates the clinical course of the process. As aresult, MCs change their secretory profile, interfere in the realization of cardiac functions against thebackground of inflammation, but at the same time modulate the afferent information flow from the heartand efferent influences of the nervous system. The coordinated activity of the system loses its stability,leading as a rule to severe consequences for the whole organism. The current status quo analysis of theproblem indicates that cardiac activity depends on the functional state of MCs and their complexinteraction with the nervous system both under normal conditions and, especially, against thebackground of developing pathological processes.https://doi.org/10.1134/S0022093024020145
Добавил в систему: Морозова Мария Павловна

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