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Sevoflurane multiple Wash In/Wash Out at the end of anesthesia to reduce agitation: A multicenter double-blind randomized controlled trialстатья
- Авторы: Landoni Giovanni, Likhvantsev Valery V., Berikashvili Levan B., Yavorovsky Andrey G., Bagdasarov Pavel S., Smirnova Anastasia V., Serkova Tatiana S., Subbotin Valery V., Kadantseva Kristina K., Ovezov Alexey M., Yadgarov Mikhail Ya, Yakovlev Alexey A., Lamacchia Andrea, Gallo Lorenzo, Gracheva Nadezhda D., Ryzhkov Pavel V., Zilocchi Rachele, De Vecchi Jessica, Aleinikov Maksim A., Mayuk Pavel S., Pivovarova Alina A., Shemetova Maria M.
- Журнал: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
- Том: 39
- Год издания: 2024
- DOI: 10.1016/j.conctc.2024.101316
- Аннотация: BackgroundPostoperative agitation is common after non-cardiac surgery. It is associated with postoperative delirium and cognitive dysfunction, leading to prolonged hospital stay and delayed social readjustment. Prevention and treatment strategies are lacking. We assessed the efficacy of a novel approach, the Wash In/Wash Out procedure, in reducing post-anesthetic agitation.MethodsThis multicenter, parallel-group, double-blind randomized controlled trial is enrolling 200 patients undergoing open abdominal surgery. Participants are randomly assigned to either a control group receiving standard recovery methods or an investigational group undergoing the Wash In/Wash Out procedure. In the Wash In/Wash Out procedure group, sevoflurane is stopped and then promptly restarted when the patient shows the first signs of awakening to achieve an end-tidal concentration of 1 minimum alveolar concentration (MAC) for 5 min. This stop-and-restart cycle is performed three times. The trial's primary outcome is the rate of postoperative agitation. Secondary outcomes include rate of postoperative delirium and cognitive dysfunction, postoperative nausea and vomiting, and length of intensive care and hospital stay.DiscussionThe OPERA trial investigates the effect of the Wash In/Wash Out procedure to reduce post-anesthetic agitation in non-cardiac surgery. This study could offer a significant contribution to improving patient outcomes and optimizing recovery protocols in surgical settings.
- Добавил в систему: Ядгаров Михаил Яковлевич