The Effect of Therapy Regimen on Antitumor Efficacy of the Nanosomal Doxorubicin against Rat Glioblastoma 101.8

Alekseeva, A.I.; Khalansky, A.S.; Miroshnichenko, E.A.; Gerasimov, A.D.; Sentyabreva, A.V.; Kudelkina, V.V.; Osipova, N.S.; Gulyaev, M.V.; Gelperina, S.E.; Kosyreva, A.M.

Авторы: Alekseeva A.I., Khalansky A.S., Miroshnichenko E.A., Gerasimov A.D., Sentyabreva A.V., Kudelkina V.V., Osipova N.S., Gulyaev M.V., Gelperina S.E., Kosyreva A.M.
Журнал: Bulletin of Experimental Biology and Medicine
Том: 176
Год издания: 2024
Издательство: Springer Nature
Местоположение издательства: Switzerland
Первая страница: 697
Последняя страница: 702
DOI: 10.1007/s10517-024-06092-1
Аннотация: One of the key problems of glioblastoma treatment is the low effectiveness of chemotherapeutic drugs. Incorporation of doxorubicin into PLGA nanoparticles allows increasing the antitumor effect of the cytostatics against experimental rat glioblastoma 101.8. Animal survival, tumor volume, and oncogene expression in tumor cells were compared after early (days 2, 5, and 8 after tumor implantation) and late (days 8, 11, and 14) start of the therapy. At late start, a significant increase in the expression of oncogenes Gdnf, Pdgfra, and Melk and genes determining the development of multidrug resistance Abcb1b and Mgmt was revealed. At early start of therapy, only the expression of oncogenes Gdnf, Pdgfra, and Melk was enhanced. Early start of treatment prolonged the survival time and increased tumor growth inhibition by 141.4 and 95.7%, respectively, in comparison with the untreated group; these differences were not observed in the group with late start of therapy. The results indicate that the time of initiation of therapy is a critical parameter affecting the antitumor efficacy of DOX-PLGA.
Добавил в систему: Гуляев Михаил Владимирович

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ЦЭМИ РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ЦЭМИ РАН

The Effect of Therapy Regimen on Antitumor Efficacy of the Nanosomal Doxorubicin against Rat Glioblastoma 101.8статья Исследовательская статья

Прикрепленные файлы