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Cu (II) and Ni (II) complexes of 1-(N-phenylthiocarbamoyl)-pyrazolines: Synthesis, electrochemistry and cytotoxic propertiesстатья Электронная публикация
- Авторы: Vorozhtsov Nikolai I., Korablina Diana D., Kalenikova Elena I., Sviridova Lyudmila A., Petkova Aneliia, Moiseeva Anna A., Tafeenko Viktor A., Ataeva Aida N., Makhmudova Bakhu V., Markova Alina A., Shtil Alexander A., Zyk Nikolai V., Beloglazkina Elena K.
- Журнал: Results in Chemistry
- Год издания: 2024
- Издательство: Elsevier B.V.
- Местоположение издательства: Netherlands
- Первая страница: 1
- Последняя страница: 16
- Номер статьи: 101632
- DOI: 10.1016/j.rechem.2024.101632
- Аннотация: Two series of novel Cu (II) (4a-e) and Ni (II) (5a-e) complexes bearing 1-(N-phenylthiocarbamoyl)-pyrazoline ligands(3a-e) were synthesized and characterized. The structures of Ni (II) complexes 5a, c were confirmed by X-ray crystallography; bothcomplexes have a distorted octahedral coordination environment of the Ni (II); metal atoms are coordinated by pyridyl andpyrazoline nitrogen atoms and thiocarbonyl sulfur of two ligand moiety, with two chloride anions in the outer sphere. The Cu (II)complex 4a derived from ligand 3a demonstrate a non-typical electrochemical behavior indicating Cu (I) complex formation whichcan be explained either by pyrazoline ligand ring opening in DMF solution or by a non-innocent nature of 3a. All of the synthesizedcomplexes were cytotoxic against HCT116 and К562 cell lines; the most cytotoxic ligand was 3d, which is structurally related tocombretastatin A4.
- Добавил в систему: Каленикова Елена Игоревна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Results_in_chem_2024_Korablina.pdf | Results_in_chem_2024_Korablina.pdf | 880,0 КБ | 4 июля 2024 [Elena_Kalenikova] |