7-Methylguanine inhibits colon cancer growth in vivo

Авторы: Kirsanov K.I., Fetisov T.I., Antoshina E.E., Gor’kova T.G., Trukhanova L.S., Shram S.I., Nagaev I.Yu, Zolotarev Yu A., Abo Qoura L., Pokrovsky V.S., Yakubovskaya M.G., Švedas V.K., Nilov D.K.
Журнал: Acta Naturae (англоязычная версия)
Том: 16
Номер: 2
Год издания: 2024
Издательство: Park Media Ltd
Местоположение издательства: Moscow, Russia (Federation)
Первая страница: 50
Последняя страница: 52
DOI: 10.32607/actanaturae.27422
Аннотация: 7-Methylguanine (7-MG) is a natural inhibitor of poly(ADP-ribose) polymerase 1 and tRNA-guanine transglycosylase, the enzymatic activity of which is central for the proliferation of cancer cells. Recently, a number of preclinical tests have demonstrated the safety of 7-MG and a regimen of intragastric administration was established in mice. In the present work, the pharmacological activity of 7-MG was studied in BALB/c and BALB/c nude mice with transplanted tumors. It was found that 7-MG effectively penetrates tumor tissue and suppresses colon adenocarcinoma growth in the Akatol model, as well as in a xenograft model with human HCT116 cells.
Добавил в систему: Нилов Дмитрий Константинович

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