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Synthesis of Pregna-1,4,16-triene-3,20-dione from a Mixture of Soybean Phytosterols using a Combination of Chemical and Microbiological Methodsстатья
- Авторы: Huy Luu D., Savinova Tatiana S., Kazantsev Alexey V., Fokina Victoria V., Donova Marina V.
- Журнал: Current Organic Chemistry
- Том: 28
- Год издания: 2024
- Издательство: Bentham Science Publishers
- Местоположение издательства: Netherlands
- DOI: 10.2174/0113852728317835240812102433
- Аннотация: In this paper, we present an efficient procedure for the transformation of a soy-bean phytosterol mixture into pregna-1,4,16-triene-3,20-dione, which is a key intermediate for the synthesis of valuable corticoids. The possibility of using two alternative methods for 1(2)-dehydrogenation of pregna-4,16-diene-3,20-dione - chemical and microbiological - was shown. Microbiological 3-keto-4-ene steroid 1(2)-dehydrogenation was carried out using actinobacterial cells of Nocardioides simplex VKM Ac-2033D. The structures of the synthesized compounds were confirmed by the IR, MS, and 1H-NMR methods
- Добавил в систему: Казанцев Алексей Витальевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | BMS-COC-2024-104-MS.pdf | 560,3 КБ | 2 сентября 2024 [KazantsevAV] |