Active Avoidance Learning in Rats with Different Audiogenic Epilepsy Proneness

Surina, N.M.; Fedotova, I.B.; Poletaeva, I.I.

Авторы: Surina N.M., Fedotova I.B., Poletaeva I.I.
Журнал: Journal of Evolutionary Biochemistry and Physiology
Том: 60
Номер: 4
Год издания: 2024
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 1555
Последняя страница: 1561
DOI: 10.1134/s0022093024040239
Аннотация: —Learning difficulties are a fairly common comorbid complication in patients diagnosed withepilepsy. The relationship between the predisposition to epilepsy and the ability to learn is an importantproblem. The aim of the study was to analyze how the learning capacity differs in rats with differentpredispositions to reflex audiogenic epilepsy (AE). The success of active avoidance (AAC) conditioningin the shuttle box in rats of 3 strains was evaluated. These were rats predisposed to audiogenic epilepsy—the Krushinsky–Molodkina strain (KM), strain “4” (selected from a population of F2 hybrids of the KMstrain and AE non-prone Wistars) and rats of “0” strain, selected for the absence of AE from the samepopulation (i.e. these strains differ radically in AE-proneness, but have a similar genetic background).The training was conducted continuously for 5 days (20 presentations per day). Experiments have shownsignificantly more successful acquisition of this skill in rats of the “0” strain: in total, 75% of animalsreached the learning criteria for 5 days of AAC training (70% AAC per day). The “4” strain rats indiceswere intermediate—41.7%, and only 1 from the 12 rats of the KM strain (8.3%) acquired the taskaccording to this protocol. Thus, it was possible to identify more successful learning in rats, selected forthe absence of AE seizures (strain “0”) compared to rats of the KM and “4” strains (expressing tonicseizures of maximum intensity in response to sound exposure). The weakest acquisition was revealed inthe KM strain, in which the selection process duration for AE proneness was significantly longer than inthe rats of the “4” strain.
Добавил в систему: Сурина Наталья Михайловна

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