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Clinical and Psychometric Features of Cognitive and Negative Disorders in Schizophrenia //Neuroscience and Behavioral Physiology. – 2024. – Т. 54. – №. 6. – С. 859-865.DOI 10.1007/s11055-024-01688-60097-0549/24/5406- ©2024 Springer Nature Switzerland AGстатья
- Авторы: Chugunov D.A., Shmilovich A.A., Larina M.R., Goncharenko S.N., Moiseeva T.V., Ryauzova E.S., Fedorova E.V., Bukinich A.A.
- Журнал: Neuroscience and Behavioral Physiology
- Том: 54
- Номер: 6
- Год издания: 2024
- Издательство: Kluwer Academic/Plenum Publishers
- Местоположение издательства: United States
- Первая страница: 859
- Последняя страница: 865
- DOI: 10.1007/s11055-024-01688-6
- Аннотация: Objectives. To establish the characteristics of clinical manifestations and cognitive tests in patients with schizophrenia with a predominance of cognitive and negative disorders. Materials and methods. A total of 76 patients were examined (66 in the study group, 10 in the reference group), who were undergoing treatment at the Alekseev Psychiatric Clinical Hospital No. 1 (Moscow) and the Gannushkin Psychiatric Clinical Hospital No. 4 (Moscow). Clinical-psychopathological, psychometric, and statistical methods were used. Cognitive functioning was assessed using the Frontal Assessment Battery (FAB) and the Edinburgh Amyotrophic Lateral Sclerosis Behavioral and Cognitive Assessment Scale (ECAS). Emotional intelligence was assessed using the Ekman Facial Emotion Recognition (EFER) test. Results. Patients with schizophrenia showed dominance of one of three types of deficit symptoms: cognitive, emotional, or volitional. Cognitive functions decreased significantly in patients with schizophrenia as compared with the reference group (mean FAB score (M ± SD) 13.44 ± 2.97 in patients with schizophrenia vs. 16.10 ± 1.70 in the reference group; t = 4.10; p < 0.001). Cognitive functions were particularly decreased in patients with volitional deficits (mean total score on the EFER scale 42.40 ± 9.0 in patients with volitional deficits vs. 47.21 ± 6.33 in patients with cognitive deficits; t = 2.12; p = 0039; mean scores on the FAB scale were 12.83 ± 3.29 in patients with vo- litional deficiency vs. 16.10 ± 1.70 in patients in the reference group; p < 0.001; mean scores on the ECAS, which is specific for ALS, were 78.80 ± 9.07 in patients with volitional deficiency and 84.50 ± 6.71 in patients from the reference group; t = 2.18; p = 0.034). Conclusions. The greatest contribution to the development of cognitive impairment in schizophrenia was made by dysfunction of the frontal (especially) and temporal cortex. Executive functions, language skills, and verbal fluency were the most affected.
- Добавил в систему: Букинич Арина Александровна