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Tissues Protein Microenvironment and Survival by Age at Cancersстатья
- Автор: Shoutko Aleksey N.
- Журнал: Acta Scientific Cancer Biology
- Том: 6
- Номер: 7
- Год издания: 2022
- Издательство: Acta Scientific Publications Opc Private Limited
- Местоположение издательства: India
- Первая страница: 1
- Последняя страница: 9
- DOI: 10.31080/ASCB.2022.06.0380
- Аннотация: Introduction: Three general types of survival by age characterize the effectiveness of conventional cancer treatment in a populationof developed country. To explain big difference between received results, the microenvironment of normal tissues investigated andcompared with clinical data.Material and Method: Open database for cancer survival by age in UK and open database for human proteins in normal humantissues used for extraction of original information for 16 cancers and 18 proteins in normal tissues, which are host/primary forcorresponding malignancy. All original data for protein levels transformed by normalization to level in bone marrow. The transformeddata were analyzed and compared with three general types survival by age, using statistical instruments of Excel.Results: Three cohorts of sixteen cancers of UK population’s data differ around 7 times according to exponential rate of survival’sdecline by age. The average result of therapy in cohorts is better, the higher the average level of markers for hematopoietic (CD34)and vasculogenic (CD31) cells in normal tissues corresponded to cancer’s cohorts. The level of immune markers for T-, B-cells, andneutrophils in normal tissues are lower, than stem cells, young lymphoid descendants, and endothelial ones. The result of therapyin cohorts is the better, the lover level of immune markers in normal tissues, corresponded to cohorts i.e. the more shift to the"stemness" in the differentiation's range. The number of markers for hematopoietic stem cells and their descendants in normaltissues varies in the opposite way.Discussion: Despite common domination of hematopoietic stem cells markers in normal tissues, their number may vary byphysiology of inter-organs flows of the fluids. The higher morphogenic resource of CD34 and CD31 in normal tissue can extend thelocal tumor growth, delay a coming hypoxia, metastases, and death.Conclusion: The proteins microenvironment of normal human tissues, as a host of unpredictable malignancy, does not correspondcompletely to the usual markers in terms of circulating blood cells. The domination of “CD34- stemness” and “CD31-vasculogenity”provide a local longevity of tumor and thus delay the shift of its logarithmic growth into quasi-linear, the offensive of hypoxia, followedmetastases and death (PDF) Acta Scientific CANCER BIOLOGY (ISSN: 2582-4473) Tissues Protein Microenvironment and Survival by Age at Cancers. Available from: https://www.researchgate.net/publication/363566713_Acta_Scientific_CANCER_BIOLOGY_ISSN_2582-4473_Tissues_Protein_Microenvironment_and_Survival_by_Age_at_Cancers [accessed Nov 06 2024].
- Добавил в систему: Шутко Алексей николаевич