YAP/TAZ Signalling Controls Epidermal Keratinocyte Fate

Pankratova, M.D.; Riabinin, A.A.; Butova, E.A.; Selivanovskiy, A.V.; Morgun, E.I.; Ulianov, S.V.; Vorotelyak, E.A.; Kalabusheva, E.P.

Авторы: Pankratova Maria D., Riabinin Andrei A., Butova Elizaveta A., Selivanovskiy Arseniy V., Morgun Elena I., Ulianov Sergey V., Vorotelyak Ekaterina A., Kalabusheva Ekaterina P.
Журнал: International Journal of Molecular Sciences
Том: 25
Номер: 23
Год издания: 2024
Издательство: MDPI
Местоположение издательства: Basel, Switzerland
Первая страница: 12903
Последняя страница: 12903
DOI: 10.3390/ijms252312903
Аннотация: The paralogues Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) control cell proliferation and cell fate determination from embryogenesis to ageing. In the skin epidermis, these proteins are involved in both homeostatic cell renewal and injury-induced regeneration and also drive carcinogenesis and other pathologies. YAP and TAZ are usually considered downstream of the Hippo pathway. However, they are the central integrating link for the signalling microenvironment since they are involved in the interplay with signalling cascades induced by growth factors, cytokines, and physical parameters of the extracellular matrix. In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.
Добавил в систему: Ульянов Сергей Владимирович

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