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Glycan microarray studies with vaginal bacteria reveal novel glycan interactions implicated in reproductive health and diseaseстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Tajadura-Ortega Virginia, Chai Wengang, Roberts Lauren, Zhang Yibing, Di Maio Antonio, Decout Alexiane C., Riaposova Lucia, Palma Angelina, Pinheiro Benedeta, De Nicola Gian, Gimeno-Molina Belen, Lee Yun S., Cao Hongzhi, Piskarev Vladimir, Dias da Costa Tiago R., Amin Himani, Akune Yukie, Sykes Lynne, Bennett Phillip R., Marchesi Julian R., Ten Feizi, Liu Yan, MacIntyre David
- Журнал: Nature communications
- Год издания: 2025
- Издательство: Nature Pub. Group
- Местоположение издательства: United Kingdom
- DOI: 10.1038/s41467-025-60404-1
- Аннотация: Lactobacillus displacement from the vaginal microbiome associates with adverse health outcomes and is linked to increased risk of preterm birth. Glycans mediate bacterial adhesion events involved in colonisation and infection. Using customised glycan microarrays, we establish glycan interaction profiles of vaginal bacteria implicated in reproductive health. Glycan binding signatures of the opportunistic pathogens Escherichia coli, Fusobacterium nucleatum and Streptococcus agalactiae to oligomannose N-glycans, galactose-terminating glycans and hyaluronic acid, respectively are highly distinct from Lactobacillus commensals. Binding to sulphated glycosaminoglycans by vaginal bacteria is pH dependent, as is binding to neutral and sialic acid-terminating glycans by F. nucleatum. Adhesion of Lactobacillus crispatus, Lactobacillus iners, Gardnerella vaginalis, S. agalactiae and F. nucleatum to vaginal epithelial cells is partially mediated by chondroitin sulphate. S. agalactiae binding to chondroitin sulphate C oligosaccharides is inhibited by L. crispatus. This study highlights glycans as mediators of vaginal bacterial binding events involved in reproductive health and disease.
- Добавил в систему: Пискарев Владимир Евгеньевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Nature_Communications_paper.pdf | Nature_Communications_paper.pdf | 4,1 МБ | 9 июня 2025 [PiskarevVE] | |
| 2. | Экспертное_заключение_Nature_Communications.jpg | Экспертное_заключение_Nature_Communications.jpg | 720,3 КБ | 2 декабря 2024 [PiskarevVE] |