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Radioprotective Properties of Fullerenol: Cellular, Biochemical and Physicochemical Approachesстатья Исследовательская статья
- Авторы: Kolesnik Olga V., Grabovoy Aleksey S., Badun Gennadii A., Churilov Grigoriy N., Kudryasheva Nadezhda S.
- Журнал: Eurasian Journal of Chemistry
- Том: 29
- Номер: 3 (115)
- Год издания: 2024
- Издательство: Karagandy University of the name of academician E.A. Buketov
- Местоположение издательства: Kazakhstan
- Первая страница: 72
- Последняя страница: 81
- DOI: 10.31489/2959-0663/3-24-9
- Аннотация: The search for optimal radioprotective methods and tools under low-dose radiation exposures represents a pressing issue in the field of modern radioecology. The objective of the study was to investigate the radiopro-tective properties of fullerenol C60,70Oy(OH)x, (x+y = 24–28), a water-soluble polyhydroxylated fullerene de-rivative with an electron-deficient aromatic carbon structure. Tritium, a radionuclide of low decay energy, was selected to simulate an exposure to low-dose irradiation (< 0.05 Gy). We applied luminous marine bacte-ria Photobacterium phosporeum as a model cellular object to monitor radiation bioeffects; the biolumines-cence intensity of the bacteria was used as a tested biological parameter. Tritium activated the bacterial lumi-nescence; the addition of fullerenol (< 3·10^–3 g/L) “mitigated” the activation, thus revealing the radioprotec-tive capacity of fullerenol for the marine microorganism. To evaluate the mechanisms of radioprotection of fullerenol in tritiated water, we investigated the effects of fullerenol on: (1) the content of reactive oxygen species and (2) the intensity of bioluminescence in the bacterial enzymatic reaction. Tritiated water produced moderate deviations from the control values, whereas the addition of fullerene brought these values closer to the “control” ones. All observed effects were attributed to variations in the ionic balance of the aqueous medium, which resulted in the activation of bacterial functions through cell membranes.
- Добавил в систему: Бадун Геннадий Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | 2024_Eurasian_Journal_of_Chemistry_29_3115_7281.pdf | 503,8 КБ | 12 декабря 2024 [Badun_GA] |