Expression of Somatic Multiple Drug Resistance Genes, mdr1a and mdr1b, is Increased with the Progression of Tuberculous Inflammation in Mice

Авторы: Erokhina MV, Nikonenko BV, Rybalkina EYu, Bocharova IV, Ergeshov AE, Sychevskaya KA, Lepekha LN
Журнал: Insights in Tuberculosis
Том: 1
Номер: 3:1
Год издания: 2017
Издательство: OPR SCIENCE
Местоположение издательства: Hyderabad
Первая страница: 2
Последняя страница: 7
Аннотация: Somatic multiple drug resistance (MDR) is a poorly understood phenomenon which was primarily manifested in the treatment of cancer. It is characterized by a reduced susceptibility of tumor cells to antitumor drugs due to a release the drugs out of the cells. So called drug resistance proteins are responsible for this phenomenon that act like pumps. Prolonged use of drugs leads to enhanced expression of the genes encoding these proteins and their increased activity. Such cellular resistance makes sense in survival of somatic cells when exposed to different harmful substances. Here we have shown that tuberculosis infection itself causes increased expression of mdr1a and mdr1b MDR proteins that along with the possible development of cellular resistance to anti-TB drugs complicates the treatment of tuberculosis.
Добавил в систему: Ерохина Мария Владиславовна

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