CS-specific modifications of auditory evoked potentials in the behaviorally conditioned rat

Leon, M.I.; Miasnikov, A.A.; Wright, E.J.; Weinberger, N.M.

Авторы: Leon M.I., Miasnikov A.A., Wright E.J., Weinberger N.M.
Журнал: Brain Research
Том: 1670
Год издания: 2017
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 235
Последняя страница: 247
DOI: 10.1016/j.brainres.2017.06.030
Аннотация: The current report provides a detailed analysis of the changes in the first two components of the auditory evoked potential (AEP) that accompany associative learning. AEPs were recorded from the primary auditory cortex before and after training sessions. Experimental subjects underwent one (n = 5) or two (n = 7) days of conditioning in which a tone, serving as a conditioned stimulus (CS), was paired with mild foot shock. Control subjects received one (n = 5) or two (n = 7) days of exposure to the same stimuli delivered randomly. Only animals receiving paired CS-US training developed a conditioned tachycardia response to the tone. Our analyses demonstrated that both early components of the AEP recorded from the granular layer of the cortex undergo CS-specific associative changes: (1) the first, negative component (occurring 21 ms following tone onset) was significantly augmented after one and two days of training while maintaining its latency, and (2) the second, positive component (occurring 50 ms following tone onset) was augmented after two days of training, and showed a significant reduction in latency after one and two days of training. We view these changes as evidence of increased cortical synchronization, thereby lending new insight into the temporal dynamics of neural network activity related to auditory learning.
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CS-specific modifications of auditory evoked potentials in the behaviorally conditioned ratстатья

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