Аннотация:Preparation of biologically active fibers based on the sodium salt of alginic acid by spinning into aprecipitation bath containing calcium ions was studied. The highly active antibacterial drugvancomycin, which should be assimilated into the body in small doses over a long time, was added tothe spinning solutions to increase the level of biological activity. The effects of spinneret andorientational drawing on wet spinning and the physicomechanical properties of the alginate fiberswere studied on a test stand. The kinetic laws were established. A mechanism of vancomycin releasefrom the biologically active alginate fibers was proposed. The studied systems based on biologicallyactive fibers of cross-linked alginate after textile processing could be used as bandages or transdermalvancomycin dosage forms.
