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Exercise-induced expression of peroxisome proliferator-activated receptor γ coactivator-1α isoforms in skeletal muscle of endurance-trained malesстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 ноября 2014 г.
- Авторы: Popov DV, Bachinin AV, Lysenko EA, Miller TF, Vinogradova OL
- Журнал: The Journal of Physiological Sciences
- Том: 64
- Номер: 5
- Год издания: 2014
- Издательство: Physiological Society of Japan
- Местоположение издательства: Japan
- Первая страница: 317
- Последняя страница: 323
- DOI: 10.1007/s12576-014-0321-z
- Аннотация: The aim of the present study was to investigate the effect of acute aerobic exercise on the expression of PGC-1α transcript variants in human skeletal muscle. Seven endurance-trained athletes performed a 90 min cycling test (62% of о2max). At resting state, the levels of N-truncated (NT)-PGC-1α and PGC-1α exon 1a-derived transcripts were significantly higher (>20-fold; P<0.05) than those of PGC-1α exon 1b and 1c-derived transcripts. Acute exercise did not change the PGC-1α exon 1a-derived expression level, but it did increase the expression level of NT-PGC-1α mRNAs 6-fold, and the expression levels of PGC-1α exon 1b and 1c-derived mRNAs >200-fold (P<0.05). We conclude that NT-PGC-1α transcript expression in resting muscle and after acute moderate-intensity exercise constituted a significant share of total PGC-1α expression. The exercise led to a higher level of PGC-1α expression from alternative promoters (exon 1b and 1c-derived mRNA) than from the canonical proximal promoter (exon 1a-derived mRNA).
- Добавил в систему: Попов Даниил Викторович